一般情况
姓名：胡容
性别：女
学科专业：肿瘤药理学
职务职称：教授
最高学历及毕业时间：博士，2005年
联系方式：13770823968，michelhu#hotmail.com
学习、工作经历
2008年-今 中国药科大学生理教研室 教授
1999年-2005年 美国Rutgers University 药学博士
专业研究方向
肿瘤药理学
主要科研工作简介：
具体研究领域
在美国Rutgers大学留学期间主要从事肿瘤的化学预防药物研究，已发表相关SCI论文二十余篇，开发的结肠癌预防药物在美国已进入II期临床。现阶段主要研究方向是：1）从天然产物中寻找新型化学预防药物并进行机制研究；2）在细胞、分子和整体水平上，建立基于阻断炎-癌转化的新型肿瘤预防药物的药效学评价体系，为发现更多高效低毒的肿瘤预防药物奠定基础；3）肿瘤多药耐药的逆转及其机制研究。
课题资助
国家自然科学基金，江苏省自然科学基金，863计划重大项目基金，国家新药创制重大专项平台等
近期代表性论文
1. Rong JJ,Hu R (co-contributing author),Qi Q,Gu HY,Zhao Q,Wang J,Mu R,You QD,Guo QL. Gambogic acid down-regulates MDM2 oncogene and induces p21(Waf1/CIP1) expression independent of p53. Cancer Lett. 2009 May 8. [Epub ahead of print]
2. Sun Y,Lu N,Ling Y,Gao Y,Chen Y,Wang L,Hu R,Qi Q,Liu W,Yang Y,You Q,Guo Q. Oroxylin A suppresses invasion through down-regulating the expression of matrix metalloproteinase-2/9 in MDA-MB-435 human breast cancer cells. Eur J Pharmacol. 2009 Jan 28; 603(1-3):22-8.
3. Peng J,Qi Q,You Q,Hu R,Liu W,Feng F,Wang G,Guo Q. Subchronic toxicity and plasma pharmacokinetic studies on wogonin,a natural flavonoid,in Beagle dogs. J Ethnopharmacol. 2009 Jul 15;124(2):257-62.
4. Shen G,Khor TO,Hu R,Yu S,Nair S,Ho CT,Reddy BS,Huang MT,Newmark HL,Kong AN. Chemoprevention of familial adenomatous polyposis by natural dietary compounds sulforaphane and dibenzoylmethane alone and in combination in ApcMin/+ mouse. Cancer Res. 2007 Oct 15;67(20):9937-44.
5. Hu R,Khor T,Shen G,Joeng WS,Hebbar V,Chen C,Xu C,Reddy B,Chada K,Kong AN. Cancer Chemoprevention of Intestinal Polyposis in Apc+/Min Mice by Sulforaphane,a Natural Product Derived from Cruciferous Vegetable. Carcinogenesis,2006 Oct; 27(10):2038-46.
6. Hu R,Xu C,Shen G,Jain MR,Khor TO,Gopalkrishnan A,Lin W,Reddy B,Chan JY,Kong AN. Gene expression Profiles Induced by Cancer Chemopreventive Isothiocyanate Sulforaphane in the Liver of C57BL/6J Mice and C57BL/6J/Nrf2 (-/-) Mice. Cancer Lett. 2006 Nov 18; 243(2):170-92.
7. Hu R,Xu C,Shen G,Jain MR,Khor TO,Gopalkrishnan A,Lin W,Reddy B,Chan JY,Kong AN. Identification of Nrf2-regulated Genes Induced by Chemopreventive Isothiocyanate PEITC by Oligonucleotide Microarray. Life Sci. 2006 Oct 12;79(20):1944-55.
8. Hu R,Shen G,Hebbar V,Xu C,Lin W,Kong AN. In vivo Pharmacokinetics,Activation of MAP and Regulation of Gene expression Elicited by Cancer Chemopreventive compound BHA in Mice. Arch Pharm Res. 2006 Oct; 29(10):911-20.
9. Khor TO,Hu R (co-contributing author),Shen G,Jeong WS,Hebbar V,Chen C,Xu C,Nair S,Reddy B,Chada K,Kong AN. Pharmacogenomics of Cancer Chemopreventive Isothiocyanate Compound Sulforaphane in the Intestinal Polyps of ApcMin/+ Mice. Biopharm Drug Dispos. 2006 Dec; 27(9):407-20.
10. Hu R,Hebbar V,Kim BR,Chen C,Winnik B,Buckley B,Soteropoulos P,Tolias P,Hart RP,Kong AN. In Vivo Pharmacokinetics and Regulation of Gene expression Profiles by Isothiocyanate Suloraphane in the Rat. J Pharmacol Exp Ther. 2004 Jul; 310(1):263-71.
11. Hu R,Kong AN. Activation of MAP kinases,Apoptosis and Nutragenomic of Gene expression Elicited by Dietary Cancer Prevention Compounds. Nutrition. 2004 Jan; 20 (1): 83-88.
12. Hu R,Kim BR,Chen C,Hebbar V,Kong AN. The Roles of JNK and Apoptotic Signaling Pathways in PEITC-mediated Responses in Human HT-29 colon Adenocarcinoma Cells. Carcinogenesis. 2003 Aug; 24 (8):1361-7.
13. Kim BR.,Hu R,Keum YS,Hebbar V,Shen G,Nair S,Kong AN. Effects of Glutathione on Antioxidant Response Element-mediated Gene expression and Apoptosis Elicited by Sulforaphane. Cancer Res. 2003 Nov 1; 63(21): 7520-5.
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